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The POISE Trial will determine the impact of perioperative administration of metoprolol on cardiovascular events (defined as cardiovascular death, nonfatal myocardial infarction, or (11) The risk to subject safety in a clinical trial mainly stems from two sources: the investigational medicinal product and the intervention. Many clinical trials, however, pose only a minimal additional risk to subject safety compared to normal clinical practice.

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In addition, we will provide to each person, who has worked in the POSE-Study according to the study delegation log, a certificate to verify their contribution to the POSE-Study. How will POSE work? Each hospital will collect data on every eligible patient who has surgery or intervention with anaesthesia care (performed by an anaesthetist) within the selected inclusion period of 30 days. The POSE procedure is considered investigational in the United States and outside of the eleven bariatric centers participating in the Essential Trial, it is performed at only a few select locations around the county.